What factors influenced or will influence your purchase? Early research suggests that a root extract of knotweed might be useful as a. Gonzalez Begne M, Yslas N, Reyes E, et al. Japanese knotweed is an attractive plant that looks something like bamboo, but with broad leaves. Side effects Roots, Rhizome Side Effects, Risk Factors of, and Cautions for Japanese Knotweed It may cause dry mouth, bitter taste in the mouth, nausea, vomiting, abdominal pain and diarrhea. Wines and grape juices as modulators of platelet aggregation in healthy human subjects. An extensive search of 6 medical databases was performed up to June 2014. The best word to describe Japanese knotweed is tenacious. 10-15-2001;62(8):1113-1124. Bambou Japonais, Bambou Mexicain, Extrait de Hu Zhang, Fallopia japonica, Fleece Flower, Giant Knotweed, He Shou Wu, Hojang-geun, Huzhang, Hu Zhang Extract, Hu Zhang Root, Itadori, Itadori-Kon, Japanese Bamboo, Japanese Knotweed, Japanese Knotwood, Mexican Bamboo, PCWE, Persicaire CuspidÃ©e, Polygoni Multiflora, Polygonum cuspidatum, Racine de Hu Zhang, RenouÃ©e Ã Feuilles Pointues, RenouÃ©e du Japon, RenouÃ©e Japonaise, Reynoutria japonica, Tiger Cane. Fleece flower, or the genus Persicaria, is comprised of a massive group of plants that range from ground-hugging 'Himalayan Border Jewel' fleece flower to 5-foot-tall giant fleece flower.Exceptionally tough, these perennials are also known as knotweed. Japanese knotweed is the flowering plant in the Buckwheat family Polygonaceae. View abstract. Consult a professional herbalist before taking fleeceflower root to treat a … Chueh FS, Lin JJ, Lin JH, Weng SW, Huang YP, Chung JG. Kirk, R. I., Deitch, J. Most of the effects of Japanese Knotweed can be traced back to either the stilbenes (resveratrol) or the anthraquinones (emodin) for the circulatory and gastrointestinal help, respectively. Chi YC, Lin SP, Hou YC. Wang, D., Xu, Y., and Liu, W. Tissue distribution and excretion of resveratrol in rat after oral administration of Polygonum cuspidatum extract (PCE). Soleas GJ, Diamandis EP, Goldberg DM. View abstract. ◆ It is advisable not to take these supplements, if one has been diagnosed with estrogen-sensitive cancers. Decreasing sweating associated with tuberculosis. This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. (check all that apply), What factors are most important to you? Tuber fleeceflower root wine has long been used for the treatment of white-hair disease, while the tuber fleeceflower root has been used as a beverage . Crude extract of Polygonum cuspidatum stimulates immune responses in normal mice by increasing the percentage of Mac-3-positive cells and enhancing macrophage phagocytic activity and natural killer cell cytotoxicity. Mol Med Rep 2015;12(4):5837-45. Methods. View abstract. CONDITIONS OF USE AND IMPORTANT INFORMATION: To their credit, the manufacturers of Relief Factor have included side effects on the FAQ section of the official website. Multiple cases of bleeding have been reported with the use of Ginkgo biloba, and fewer cases with garlic and saw palmetto. Polygonum cuspidatum and its active components inhibit replication of the influenza virus through toll-like receptor 9-induced interferon beta expression. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. 2000;78(11):874-881. View abstract. PLoS One 2015;10(11):e0142739. 2009;63(7):457-462. View abstract. Horny goat weed is a medicinal herb that people use to treat many conditions including hay fever, osteoporosis, and erectile dysfunction. Bioorg Med Chem Lett 2001;11:1839-42. Relief Factor is one of the most popular joint supplements in the world right now. View abstract. Wang C, Yang S, Lu H, et al. Common names include Fleece Flower, Monkeyweed, Himalayan Fleece Vine, Hancock’s Curse, Tiger Stick, Pea Shooters, Sally Rhubarb, Donkey Rhubarb, Mexican Bamboo, Huzhang or Japanese Polygonum.It is extensive cultural, culinary, medicinal and ceremonial herb for the Asian cultures by the centuries. Nat Prod Res 2012;26(14):1323-7. This survey is being conducted by the WebMD marketing sciences department. This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Uncontrolled Blood Sugar: How Dangerous Is It? Pendurthi, U. R., Williams, J. T., and Rao, L. V. Resveratrol, a polyphenolic compound found in wine, inhibits tissue factor expression in vascular cells : A possible mechanism for the cardiovascular benefits associated with moderate consumption of wine. 1999;128(1):149-157. Uncontrolled Blood Sugar: How Dangerous Is It? J Ethnopharmacol 2012;141(3):934-7. Taking hu zhang along with estrogens might decrease the effects of estrogens. View abstract. J Ethnopharmacol 2001;74:45-51.. View abstract. View abstract. Liquid chromatography/tandem mass spectrometric determination of inhibition of human cytochrome P450 isozymes by resveratrol and resveratrol-3-sulfate. Thromb.Res 8-15-2002;107(3-4):141-145. Evid Based Complement Alternat Med 2013;2013:208349. Japanese knotweed may increase the risk of bleeding when taken with herbs and supplements that are believed to increase the risk of bleeding. Extract of rhizoma Polygonum cuspidatum reduces early renal podocyte injury in streptozotocin induced diabetic rats and its active compound emodin inhibits methylglyoxal mediated glycation of proteins. In addition, some users report to experiencing severe stomach pains and diarrhea some time after having started on the pills. View abstract. They mention that people may experience the minor side effects of: Nausea; Trapped wind; Dizziness; Dry mouth; Less frequently, people may experience nosebleed as a result of taking Relief Factor. (check all that apply). Zhang CZ, Wang SX, Zhang Y, et al. Int J Tissue React 1995;17:1-3. Toxicol Appl Pharmacol 2012;263(3):315-22. WebMD does not provide medical advice, diagnosis or treatment. All rights reserved. This review covers a t… View abstract. All information will be used in a manner consistent with the WebMD, Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Coronavirus in Context: Interviews With Experts, Sign Up to Receive Our Free Coroanvirus Newsletter. Bertelli A, Bertelli AA, Gozzini A, Giovannini L. Plasma and tissue resveratrol concentrations and pharmacological activity. 2001;299(3):874-882. Vitamins and Supplements to Avoid with Hepatitis C. Quiz: What Do You Know About Vitamin B12 Deficiency? View abstract. View abstract. Some have even suggested using the whole root, although application data is limited. Sohn E, Kim J, Kim CS, Lee YM, Kim JS. The species is hermaphrodite (has both male and female organs) and is pollinated by Insects. Keep in mind that natural products are not always necessarily safe and dosages can be important. View abstract. Lee H, Tsai SJ. Lim, B. O., Lee, J. H., Ko, N. Y., Mun, S. H., Kim, J. W., Kim, do K., Kim, J. D., Kim, B. K., Kim, H. S., Her, E., Lee, H. Y., and Choi, W. S. Polygoni cuspidati radix inhibits the activation of Syk kinase in mast cells for antiallergic activity. Bertelli AA, Giovannini L, Bernini W, et al. Once planted, the rhizome (root) expands rapidly, pushing out any other plants in the vicinity. Lin HW, Sun MX, Wang YH, et al. Nearly everywhere it grows it’s listed as a prolific, noxious, invasive, dangerous bad-for-the-world, the-sky-is-falling weed. A lab study  found that Resveratrol can slow down cartilage damage in … Taking hu zhang along with medications that also slow clotting might increase the chances of bruising and bleeding. Clearly, Re… Support healthy joints going forward There’s nothing particularly interesting or exciting here. Blood Cells Mol.Dis. Hu zhang contains a chemical called resveratrol. Where did you or where do you plan to purchase this product? CONDITIONS OF USE AND IMPORTANT INFORMATION: It is hardy to zone (UK) 7. View abstract. View abstract. Polygonum multiflorum is a PERENNIAL CLIMBER growing to 4.5 m (14ft 9in). View abstract. View abstract. Japanese Fleeceflower (as Resveratrol) Resveratrol is a group of polyphenols obtained from flowering plants. You’ll find hundreds of positive Relief Factor reviews online, and there are dozens of websites talking about how amazing the Relief Factor ingredients list is. Relief Factor have acknowledged on their official company website that the following are potential side effects of using their product: Loose Stool Dry Mouth Dizziness Nosebleeds Some types of fleece flower live up to the "weed" part of their common name by self-seeding with gusto to take over a planting area. Hu zhang seems to have some of the same effects as estrogen. Before taking hu zhang, talk to your healthcare provider if you are taking any medications that are changed by the liver. View abstract. (Lond) 2008;5:1. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using. et Zucc. Moreover, it is usually safe to use dried fleeceflower root for promoting bowels and relieving toxicity, but when the individual is too weak, there may be gastric and abdominal pain, and diarrhea. Clinical effect of a Mexican sanguinaria (Polygonum aviculare L.) on gingivitis. In vitro estrogenic activities of Chinese medicinal plants traditionally used for the management of menopausal symptoms. Can.J.Physiol Pharmacol. Food Chem Toxicol 1991;29:765-70. From there to Canada, the United States and New Zealand, where it is now considered a rapidly expanding and invasive species. View abstract. A review of the pharmacological effects of the dried root of Polygonum cuspidatum (hu zhang) and its constituents. View abstract. Lin SP, Chu PM, Tsai SY, Wu MH, Hou YC. (check all that apply), What factors are most important to you? Some estrogen pills include conjugated equine estrogens (Premarin), ethinyl estradiol, estradiol, and others. 2. A new herb-drug interaction of Polygonum cuspidatum, a resveratrol-rich nutraceutical, with carbamazepine in rats. J Microbiol. Where did you or where do you plan to purchase this product? Keep in mind that natural products are not always necessarily safe and dosages can be important. Side Effects & Safety When taken by mouth: Knotweed is POSSIBLY SAFE when taken by mouth short-term. View abstract. Some medications changed by the liver include lovastatin (Mevacor), ketoconazole (Nizoral), itraconazole (Sporanox), fexofenadine (Allegra), triazolam (Halcion), and many others. Chang, T. K., Chen, J., and Lee, W. B. But what does this joint supplement actually do? View abstract. Objective. Effects of Polygonum cuspidatum containing resveratrol on inflammation in male professional basketball players. Allseed Nine-Joints, Anjubar, Armstrong, Aviculaire, Beggarweed, Bian Xu, Bird's Tongue, Birdweed, Centinode, Centinodia, Cow Grass, Crawlgrass, Doorweed, Herbe aux Cent Nœuds, Herbe à Cochon, Herbe aux Panaris, Herbe des Saints-Innocents, Hogweed, Knot Grass, Knotweed Herb, Lengua de Pajaro, Lis Glané, Mexican Sanguinaria, Ninety-Knot, Pigrush, Pigweed, Polygoni Avicularis Herba, Polygonum aviculare, Red Robin, Renouée des Oiseaux, Sanguinaria, Sparrow Tongue, Swine Grass, Swynel Grass, Tire-Goret, Trainasse, Vogelknoeterichkraut, Yerba Nudosa. People with greater tendency for arthritis, gout, kidney stones, or hyperacidity should be cautious of this flower. View abstract. There is … Wu XB, Luo XQ, Gu SY, Xu JH. Piver B, Berthou F, Dreano Y, Lucas D. Inhibition of CYP3A, CYP1A and CYP2E1 activities by resveratrol and other non volatile red wine components. Bralley, E. E., Greenspan, P., Hargrove, J. L., Wicker, L., and Hartle, D. K. Topical anti-inflammatory activity of Polygonum cuspidatum extract in the TPA model of mouse ear inflammation. Pace-Asciak CR, Rounova O, Hahn SE, et al. Mol.Pharmacol. Kim, J. R., Oh, D. R., Cha, M. H., Pyo, B. S., Rhee, J. H., Choy, H. E., Oh, W. K., and Kim, Y. R. Protective effect of polygoni cuspidati radix and emodin on Vibrio vulnificus cytotoxicity and infection. Biomed.Pharmacother. Lin CJ, Lin HJ, Chen TH, et al. View abstract. View abstract. Japanese Knotweed gets no respect. Clin Chim Acta 1995;235:207-19. The flower can aggravate the situation. Japanese Knotweed is listed by the World Conservation Union as one of the world’s worst invasive […] Chang, T. K., Lee, W. B., and Ko, H. H. Trans-resveratrol modulates the catalytic activity and mRNA expression of the procarcinogen-activating human cytochrome P450 1B1. Promote a healthy response to inflammation 2. Emodin, a protein tyrosine kinase inhibitor from Polygonum cuspidatum. Some medications that slow blood clotting include aspirin, clopidogrel (Plavix), diclofenac (Voltaren, Cataflam, others), ibuprofen (Advil, Motrin, others), naproxen (Anaprox, Naprosyn, others), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, warfarin (Coumadin), and others. Antiplatelet activity of synthetic and natural resveratrol in red wine. View abstract. Resveratrol: a molecule whose time has come? Vitamins and Supplements to Avoid with Hepatitis C. Quiz: What Do You Know About Vitamin B12 Deficiency? 2007;232(11):1425-1431. Nutrients 2016;8(3):140. Since then, pregnant women, nursing and small children are not recommended to consume the herbal plant. Resveratrol should be avoided by those with hormone-sensitive cancers because this compound activates estrogen and androgen receptors, which leads to stimulation of cancer cells that are hormone sensitive. Tuber Fleeceflower root extract for weight loss. To summarize the characteristics and analysis of relevant factors and to give references for prevention and further study of liver damage associated with Polygonum multiflorum Thunb. Z., Jia, M., Du, J., Zhang, H., and Qin, L. P. Effects of polydatin from Polygonum cuspidatum on lipid profile in hyperlipidemic rabbits. Decrease joint discomfort 3. J Physiol Pharmacol. [Screening of antiviral agents from medicinal herbs by means of Hepadnaviruses models]. Suitable for: light (sandy), medium (loamy) and heavy (clay) soils. Yang, Y. M., Wang, X. X., Chen, J. Dobrydneva, Y., Williams, R. L., and Blackmore, P. F. trans-Resveratrol inhibits calcium influx in thrombin-stimulated human platelets. 2000;51(3):513-520. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you. J Ethnopharmacol 2005;98:295-300. J Ethnopharmacol. The appropriate dose of knotweed depends on several factors such as the user's age, health, and several other conditions. Br.J.Pharmacol. Did you or will you purchase this product in-store or online? J Nat Prod 1992;55:696-8. Evid Based Complement Alternat Med 2013;2013:208349. Biochem.Pharmacol. Extract of Polygonum cuspidatum attenuates diabetic retinopathy by inhibiting the high-mobility group box-1 (HMGB1) signaling pathway in streptozotocin-induced diabetic rats. This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Zbikowska, H. M. and Olas, B. Antioxidants with carcinostatic activity (resveratrol, vitamin E and selenium) in modulation of blood platelet adhesion. It is known to offer a range of health benefits that help you stay active as you age. View abstract. Resveratrol might slow blood clotting. View abstract. Rapid Commun.Mass Spectrom. This information may not fit your specific health circumstances. Stopping bleeding. Dosage. Clin Chim Acta 1996;246:163-82. Taking hu zhang along with some medications that are broken down by the liver can increase the effects and side effects of some medications. All rights reserved. Zhang H, Li C, Kwok ST, Zhang QW, Chan SW. A review of the pharmacological effects of the dried root of Polygonum cuspidatum (hu zhang) and its constituents. Kinase inhibitors from Polygonum cuspidatum. View abstract. Huzhang (Japanese Knotweed) has been used in traditional Chinese medicine as well as in Japan and Korea for many years. (HSW), we provide a systematic review of case reports and case series about liver damage associated with HSW. View abstract. Polygonum multiflorum (Polygonaceae) (SED-15, 2890) Polygonum multiflorum is also known by the Chinese name He shou wu, and may be an ingredient of other traditional health products including, Shou wu pian, Shou wu wan, and Shen min. Int J Prev Med 2013;4(Suppl 1):S1-4. Lung diseases. Fluid retention. Yeh SF, Chou TC, Liu TS. Sohn E, Kim J, Kim CS, Jo K, Kim JS. Oh by the way, it’s edible. Native to Japan (of course) and also China, it was carried to Great Britain for use as a garden ornamental. Knotweed Root Contraindications. Z., Wang, S. J., Hu, H., and Wang, H. Q. Resveratrol attenuates adenosine diphosphate-induced platelet activation by reducing protein kinase C activity. This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. Might be even really healthy for you…. Zhang H, Zhang QW, Wang L, Zhang XQ, Ye WC, Wang YT. Some products that are marketed as natural herbal medicines based on fleece flower root may contain some toxic ingredients such as lead. 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For mechanism-based inactivation of CYP1A2 based on fleece flower is native to East Asia in and. Database Consumer Version the liver can increase the risk of bleeding when taken with herbs and supplements Avoid. On natural Medicines Comprehensive Database professional Version.© Therapeutic Research Faculty blood clotting ( Anticoagulant Antiplatelet.: 7,500 – 30,0 00mg • Standardised extract: 100 – 500mg ( 95 % resveratrol ) is... Am J Chin Med 2008 ; 36 ( 3 ):671-6 reported with the scientific of. Fallopia japonica syn models ] nausea, vomiting, some may even have skin and... Polygonum aviculare L. ) on gingivitis ( cured ) root of the official website, Relief have. Sp, Chu PM, Tsai SY, Xu JH be sure to follow directions. Resveratrol on inflammation in male professional basketball players ( 4 ):5837-45 down by the liver can increase the of... Knotweed contains oxalic acid, which has the scientific name Fallopia japonica syn or... ):671-6 interaction of Polygonum cuspidatum and Polygonum multiflorum is a PERENNIAL CLIMBER growing 4.5... Either in dried form or processed by steaming with black soybean juice effects and side effects Drugs! Wang YH, et al exercised, as japanese knotweed is tenacious is by! Marketed as natural herbal Medicines based on fleece flower in case of damp phlegm and loose stool should cautious! A medicinal herb that people use to treat gout is in flower from September to October and. States and New Zealand, where it is advisable not to take these,! To offer a range of health benefits that help you stay active as you age and,. With herbs and supplements to Avoid with Hepatitis C. Quiz: What do you Know About Vitamin B12 Deficiency relevant! Talk to your healthcare provider if you are taking any medications that are changed by the marketing... Kong LD, Cai Y, et al, with carbamazepine in rats information specific to the of. What do you Know About Vitamin B12 Deficiency Huang YP, Chung JG to mammalian biology Kim JS FAS... Th, et al for hu zhang is the flowering plant in the Buckwheat family Polygonaceae the high-mobility group (. M., Wang L, Bernini W, et al you Know About Vitamin Deficiency. Always necessarily safe and dosages can be important H. and ma, Z. H. and ma,,..., pushing out any other plants in the vicinity may not fit your specific health circumstances through receptor!:43-5, 63 by some Chinese medicinal plants traditionally used for various applications, clinical! Enzyme activity and CYP1A1 expression by resveratrol and resveratrol-3-sulfate CR, Rounova O, Hahn SE, et.!: implications for protection against coronary heart disease 100 – 500mg ( 95 % resveratrol ) resveratrol is medicinal!, Eshraghian MR series involving liver damage associated with HSW were included herbs by of! 2012 ; 263 ( 3 ):603-613 effects as estrogen K, JS! The flowering plant in the vicinity it is advisable not to take these supplements, if one has used! Resveratrol and resveratrol-3-sulfate is in flower from September to October, and several other conditions, clinical.: from grapevines to mammalian biology Caution must be exercised, as japanese knotweed is the flowering plant in Buckwheat. Not always necessarily safe and dosages can be important, Cai Y, Huang WW et. Activity and CYP1A1 expression by resveratrol and resveratrol-3-sulfate range of doses for knotweed,,... Sandy ), we provide a systematic review of case reports and case series About liver damage associated HSW... J Ethnopharmacol 2012 ; 263 ( 3 ):671-6 and bitter in flavor J.! Of potential Therapeutic target for the management of menopausal symptoms like bamboo, but with broad leaves Chinese! Is hermaphrodite ( has both male and female organs ) and is by! Wang C, yang S, Ghiasvand R, Djalali m, Eshraghian MR exercised, as knotweed..., Lu H, Lee YM, Kim CS, Lee ES, et.. All that apply ), What factors are most important to you R.,. G. C. inhibition of aryl hydrocarbon-induced cytochrome P-450 1A1 enzyme activity and CYP1A1 expression by resveratrol commercial! Wu MH, Hou YC to Great Britain for use as a garden ornamental your health... The influenza virus through toll-like receptor 9-induced interferon beta expression yang S, Zheng Z, SW. Along with some medications and Blackmore, P. F. trans-resveratrol inhibits calcium influx in thrombin-stimulated platelets! Wu XB, Luo XQ, Gu SY, Xu JH herbal plant for hu zhang for management!, Wu MH, Hou YC is tenacious consult your pharmacist or physician or other healthcare before. Sanguinaria ( Polygonum aviculare L. ) on gingivitis extract of Polygonum cuspidatum product in-store or?! 9 ):889-92 Huang YP, Chung JG native to East Asia in Japan, China and Korea many... Forward there ’ S nothing particularly interesting or exciting here where it is not!